As global travel continues to grow, Kenya and Tanzania are once again top choices for adventure seekers. An African safari remains a bucket-list experience—and both countries offer unforgettable opportunities to see wildlife up close. Many travelers visit both in one trip. Once your flights are booked and safari tours are confirmed, your next step should be a visit to your local travel clinic.
Africa is an awe-inspiring destination—but it also comes with unique health risks. To protect yourself, it’s essential to get the right travel vaccinations, including the yellow fever vaccine. Vaccines for Kenya and Tanzania aren’t just smart—they’re essential for a safe and enjoyable journey.
Yellow Fever Vaccine for Kenya and Tanzania
First, it’s important to understand the difference between required and recommended vaccines. Under International Health Regulations, some countries require proof of yellow fever vaccination for entry. In other cases, the vaccine is simply recommended to protect you from the disease—which has no cure.
Kenya is officially considered a yellow fever–endemic country. Tanzania is not. That matters for two key reasons:
You must have a yellow fever certificate to enter Tanzania if you’re arriving from Kenya.
The vaccine is strongly recommended for travel to Kenya, but not typically required or recommended for Tanzania alone.
To further complicate matters, border agents in Zanzibar (part of Tanzania) have been known to ask for proof of yellow fever vaccination, even though this contradicts existing international health regulations.
Getting the Yellow Fever Vaccine
Deciding whether to get the yellow fever vaccine isn’t always straightforward. The rules vary based on your itinerary, and the vaccine—while highly effective—can cause side effects in some individuals.
Yellow fever vaccine is only available at certified travel clinics, where a specialist will review your medical history and travel plans to determine whether the vaccine is safe and necessary for you. It’s the best way to avoid unexpected problems at border crossings—or worse, getting sick abroad.
Routine Vaccines for Kenya and Tanzania
Before any international trip, make sure you’re up to date on routine vaccinations—those recommended even if you’re not traveling. These include:
TdaP (tetanus, diphtheria, pertussis) COVID-19 Influenza (flu shot)
Measles and polio, while rare in the U.S., still circulate in many parts of Africa. Outbreaks have been reported recently in both Kenya and Tanzania. Measles is extremely contagious, and you need two documented MMR vaccines to ensure protection. A single adult polio booster may also be advised for travel to Africa.
Hepatitis A Vaccine
Hepatitis A is a serious liver infection spread through contaminated food and water. It’s the third most common vaccine-preventable disease in the world (after COVID-19 and the flu).
While the vaccine is part of routine childhood immunization today, it wasn’t available until the late 1990s—so many adults never received it. I consider hepatitis A a “slam-dunk” vaccine for travelers: the disease is common in Africa, and the vaccine is extremely safe and effective. Two doses provide lifetime protection. Hepatitis B Vaccine
The CDC recommends hepatitis B vaccination for all adults. In Africa, hepatitis B infection rates are among the highest globally. Most children in the U.S. now receive their first dose at birth, but many adults are unvaccinated. A complete series (2 or 3 shots, depending on the type) gives lifelong protection.
Typhoid Vaccine
Typhoid fever is another food- and water-borne illness common in Kenya and Tanzania. Two vaccine options are available:
Injectable form: lasts 2 years Oral form: lasts up to 5 years
Both are highly recommended for travel to East Africa, especially for those who are visiting family and friends or engaging in mission work. Rabies Vaccine
Rabies is 100% fatal if not treated. In Africa, the main carriers are stray dogs, bats, and sometimes monkeys. A bite or scratch is a medical emergency.
Treatment can be hard to access in remote areas. Fortunately, a safe and effective pre-exposure rabies vaccine is available. Just two doses, given one week apart before your trip, offer protection and simplify emergency care if you’re exposed.
Cholera Vaccine
Cholera is on the rise in many African countries. While not recommended for every traveler, the oral Vaxchora® vaccine may be appropriate for those visiting rural areas, refugee camps, or doing mission or aid work. One dose provides protection.
Explore Africa—But Prepare First
Africa is the birthplace of humanity and one of the world’s last great wildlife frontiers. Nearly every traveler I see returns from Africa glowing with stories of unforgettable experiences. But no one wants their trip derailed by a preventable illness.
Getting the right vaccines is only part of the preparation. During your pre-travel visit, your travel health expert will also go over how to prevent malaria, insect-borne diseases, and traveler’s diarrhea.
The memories of the African savannah will last a lifetime. Book your travel clinic appointment today at TravelBug Health—so you can focus on making great memories and nothing else.
Cheers, Go Explore!
